Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.

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Article

Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.

Oncogene - 1 Aug 1993

Sarkar S, Gilmore T D

Abstract excerpt

The vRel oncoprotein of the avian Rev-T retrovirus is a member of the Rel/NF-kappa B family of transcription factors. The highly conserved amino-terminal Rel Homology (RH) domain in these proteins is required for DNA binding, protein-protein interactions and nuclear localization, and many mutatio...

Topics

Animals
Cell Transformation, Neoplastic
Chick Embryo
Chickens
DNA
Mutation
NF-kappa B
Oncogene Proteins v-rel
Promoter Regions, Genetic
Recombinant Fusion Proteins
Retroviridae Proteins, Oncogenic
Sequence Homology, Amino Acid
Structure-Activity Relationship
Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 8336947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8336947-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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