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Article

The N-terminal env-derived amino acids of v-rel are required for full transforming activity.

Virology - 1 Jul 1990

Garson K, Percival H, Kang C Y

Abstract excerpt

Expression of the v-rel oncogene of the reticuloendotheliosis virus, strain T (REV-T), can mediate the transformation of chicken spleen and bone marrow cells. Although the majority of the coding sequence of the v-rel oncogene is derived from the cellular rel sequence, the N- and C-terminal amino acids are coded for by remnants of the REV env gene. The resulting v-rel protein can be described as an env-rel-(out of...

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PMID: 2162102
DOI: 10.1016/0042-6822(90)90464-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The N-terminal env-derived amino acids of v-rel are required for full transforming activity.PMID 2162102Read ↗

Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.Semantic proximity Read ↗

Mutational analysis of v-rel, the oncogene of reticuloendotheliosis virus strain T.Semantic proximity Read ↗

Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.Semantic proximity Read ↗

The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro.Semantic proximity Read ↗

Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein.Semantic proximity Read ↗

In vivo evolution of c-rel oncogenic potential.Semantic proximity Read ↗

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Semantic proximity Read ↗

ERK and JNK activation is essential for oncogenic transformation by v-Rel.Semantic proximity Read ↗

Malignant transformation by mutant Rel proteins.Semantic proximity Read ↗

A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel.Semantic proximity Read ↗

Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.Semantic proximity Read ↗

A conditional mutant of vRel containing sequences from the human estrogen receptor.Semantic proximity Read ↗

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