Article
Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein.
Oncogene - 19 Jun 1997
Nehyba J, Hrdlicková R, Bose H R
Abstract excerpt
The oncogene v-rel of Reticuloendotheliosis virus, strain T, is derived from an avian c-rel proto-oncogene. c-rel encodes a member of the Rel/NF-kappaB family of transcription factors. The highly oncogenic v-Rel differs from c-Rel which has low transforming potential by the acquisition of numerou...
Topics
- Animals
- Binding Sites
- Cell Nucleus
- Chickens
- DNA Probes
- DNA, Viral
- DNA-Binding Proteins
- Mutation
- NF-kappa B
- Oncogenes
- Peptide Mapping
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-rel
- Reticuloendotheliosis virus
- Sensitivity and Specificity
- Turkeys