Article
In vivo evolution of c-rel oncogenic potential.
Journal of virology - 1 Apr 1994
Hrdlicková R, Nehyba J, Humphries E H
Abstract excerpt
The c-rel proto-oncogene belongs to the NF-kappa B/rel and I kappa B gene families, which regulate several inducible processes, including self-defense/repair and embryogenesis. Transduction of the c-rel transcription factor by the avian retrovirus resulted in the formation of a highly oncogenic v...
Topics
- Alpharetrovirus
- Animals
- Biological Evolution
- Cell Line
- Cell Transformation, Neoplastic
- Chickens
- Histocompatibility Antigens
- Interleukin-2
- Lymphoid Tissue
- Mutation
- Neoplasms, Experimental
- Oncogene Proteins v-rel
- Plasmids
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-rel
- Proto-Oncogenes
- Retroviridae Proteins, Oncogenic
- Sequence Deletion