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Article

Mutational analysis of v-rel, the oncogene of reticuloendotheliosis virus strain T.

Oncogene - 1 May 1990

Bhat G V, Temin H M

Abstract excerpt

Reticuloendotheliosis virus strain T (Rev-T) is a highly oncogenic retrovirus that induces a lethal lymphoma in young galliform birds and also transforms and immortalizes avian lymphoid cells in vitro. Rev-T presumably arose when a reticuloendotheliosis virus (Rev) incorporated a portion of the turkey c-rel gene into its genome, forming the v-rel oncogene. The predicted v-rel protein (p59v-rel) has 14 amino acid...

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PMID: 2189101

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Research trail→

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Mutational analysis of v-rel, the oncogene of reticuloendotheliosis virus strain T.PMID 2189101Read ↗

In vivo evolution of c-rel oncogenic potential.Semantic proximity Read ↗

The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro.Semantic proximity Read ↗

The N-terminal env-derived amino acids of v-rel are required for full transforming activity.Semantic proximity Read ↗

Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.Semantic proximity Read ↗

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Semantic proximity Read ↗

Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein.Semantic proximity Read ↗

Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.Semantic proximity Read ↗

ERK and JNK activation is essential for oncogenic transformation by v-Rel.Semantic proximity Read ↗

Malignant transformation by mutant Rel proteins.Semantic proximity Read ↗

A conditional mutant of vRel containing sequences from the human estrogen receptor.Semantic proximity Read ↗

Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.Semantic proximity Read ↗

Retrovirus-induced disease in poultrySemantic proximity Read ↗

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