Article
The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro.
Virology - 1 Aug 1991
Zhang J Y, Olson W, Ewert D, Bargmann W, Bose H R
Abstract excerpt
Heavy chain gene rearrangements were analyzed in 67 independently derived reticuloendotheliosis virus (REV-T) transformed avian lymphoid cell lines. The status of the heavy chain genes in these REV-T transformed cell lines was determined, in part, by the age of the chicken whose spleen cells were transformed. Cell lines derived by the in vitro transformation of splenic lymphocytes obtained from embryos did not...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Cell Line
- Cell Transformation, Viral
- Chick Embryo
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Lymphatic Diseases
- Oncogene Proteins v-rel
- Oncogenes
- Polymorphism, Restriction Fragment Length