Article
Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.
Molecular and cellular biology - 1 Mar 1996
White D W, Pitoc G A, Gilmore T D
Abstract excerpt
The v-Rel oncoprotein of the avian Rev-T retrovirus is a member of the Rel/NF-kappa B family of transcription factors. The mechanism by which v-Rel malignantly transforms chicken spleen cells is not precisely known. To gain a better understanding of functions needed for transformation by v-Rel, w...
Topics
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chickens
- DNA-Binding Proteins
- I-kappa B Proteins
- Molecular Sequence Data
- Mutation
- NF-KappaB Inhibitor alpha
- NF-kappa B
- Oncogene Proteins v-rel
- Protein Binding
- Retroviridae Proteins, Oncogenic