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Article

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.

Oncogene - 22 Nov 1999

Gilmore T D

Abstract excerpt

The avian Rev-T retrovirus encodes the v-Rel oncoprotein, which is a member of the Rel/NF-kappaB transcription factor family. v-Rel induces a rapidly fatal lymphoma/leukemia in young birds, and v-Rel can transform and immortalize a variety of avian cell types in vitro. Although Rel/NF-kappaB transcription factors have been associated with oncogenesis in mammals, v-Rel is the only member of this family that is...

Topics

Amino Acid Sequence
Animals
Apoptosis
Cell Division
Cell Transformation, Neoplastic
DNA
Humans
Molecular Sequence Data
Mutation
Oncogene Proteins v-rel
Protein Processing, Post-Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-rel

Structure-Activity Relationship

Transcriptional Activation

Source

Identifiers

PMID: 10602467
DOI: 10.1038/sj.onc.1203222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.PMID 10602467Read ↗

ERK and JNK activation is essential for oncogenic transformation by v-Rel.Semantic proximity Read ↗

Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein.Semantic proximity Read ↗

Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity.Semantic proximity Read ↗

Malignant transformation by mutant Rel proteins.Semantic proximity Read ↗

In vivo evolution of c-rel oncogenic potential.Semantic proximity Read ↗

Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity.Semantic proximity Read ↗

Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cells.Semantic proximity Read ↗

Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.Semantic proximity Read ↗

Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.Semantic proximity Read ↗

Mutational analysis of v-rel, the oncogene of reticuloendotheliosis virus strain T.Semantic proximity Read ↗

An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation.Semantic proximity Read ↗

Subunit-Specific Role of NF-κB in CancerSemantic proximity Read ↗

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