Article
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.
Genes & development - 1 Jul 1993
Johnson R S, van Lingen B, Papaioannou V E, Spiegelman B M
Abstract excerpt
The AP-1 transcription factors are considered immediate-early response genes and are thought to be involved in a wide range of transcriptional regulatory processes linked to cellular proliferation and differentiation. To study one of the key members of this family, the proto-oncogene c-jun, we have used homologous recombination-mediated gene targeting to produce mice with a c-jun null mutation. c-jun null embryos...
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