A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

doi:10.1101/gad.7.7b.1309

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Article

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

Genes & development - 1 Jul 1993

Johnson R S, van Lingen B, Papaioannou V E, Spiegelman B M

Abstract excerpt

The AP-1 transcription factors are considered immediate-early response genes and are thought to be involved in a wide range of transcriptional regulatory processes linked to cellular proliferation and differentiation. To study one of the key members of this family, the proto-oncogene c-jun, we ha...

Topics

Animals
Base Sequence
Cell Division
Cloning, Molecular
DNA
Female
Fetal Death
Genes, Lethal
Genes, jun
Heterozygote
Homozygote
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Proto-Oncogene Proteins c-jun

Source

Open in PubMed

Identifiers

PMID: 8330736
DOI: 10.1101/gad.7.7b.1309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8330736-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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