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Article

Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.

Immunity - 1 Apr 1994

Chen J, Stewart V, Spyrou G, Hilberg F, Wagner E F, Alt F W

Abstract excerpt

To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantial numbers of mature T and B lymphocytes in the periphery. Stimulation of c-jun-/- B cells...

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Identifiers

PMID: 7889400
DOI: 10.1016/1074-7613(94)90010-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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