Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.

doi:10.1016/1074-7613(94)90010-8

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Article

Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.

Immunity - 1 Apr 1994

Chen J, Stewart V, Spyrou G, Hilberg F, Wagner E F, Alt F W

Abstract excerpt

To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantial numbers of mature T and B lymphocytes in the periphery. Stimulation of c-jun-/- B cells...

Topics

Animals
B-Lymphocytes
Base Sequence
Cell Differentiation
Chimera
Genes, jun
Hematopoietic Stem Cells
Homozygote
In Vitro Techniques
Interleukin-2
Lymphocyte Activation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Proto-Oncogene Proteins c-jun

T-Lymphocytes

Transcription Factor AP-1

Source

Open in PubMed

Identifiers

PMID: 7889400
DOI: 10.1016/1074-7613(94)90010-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7889400-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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