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Cellular Transformation and Malignancy Induced by ras Require c-jun

1 Aug 1996

Abstract excerpt

ras is an important oncogene in experimental animals and humans. In addition, activated ras proteins are potent inducers of the transcription factor AP-1, which is composed of heterodimeric complexes of Fos and Jun proteins. Together with the fact that deregulated expression of some AP-1 proteins can cause neoplastic transformation, this finding suggests that AP-1 may function as a critical ras effector. We have...

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Identifiers

PMID: 8754851
DOI: 10.1128/mcb.16.8.4504

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