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Article

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.

Nature genetics - 1 Mar 1999

Behrens A, Sibilia M, Wagner E F

Abstract excerpt

c-Jun is a major component of the heterodimeric transcription factor AP-1 and is essential for embryonic development, as fetuses lacking Jun die at mid-gestation with impaired hepatogenesis and primary Jun-/- fibroblasts have a severe proliferation defect and undergo premature senescence in vitro. c-Jun and AP-1 activities are regulated by c-Jun N-terminal phosphorylation (JNP) at serines 63 and 73 through Jun...

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Identifiers

PMID: 10080190
DOI: 10.1038/6854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.PMID 10080190Read ↗

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The isoform‐specific functions of the c‐Jun N‐terminal Kinases (JNKs): differences revealed by gene targetingSemantic proximity Read ↗

JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.Semantic proximity Read ↗

c-jun is essential for normal mouse development and hepatogenesis.Semantic proximity Read ↗

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.Semantic proximity Read ↗

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.Semantic proximity Read ↗

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.Semantic proximity Read ↗

JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons.Semantic proximity Read ↗

c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation.Semantic proximity Read ↗

Functions of c-Jun in Liver and Heart DevelopmentSemantic proximity Read ↗

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