A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

doi:10.1101/gad.7.4.671

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Article

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

Genes & development - 1 Apr 1993

Davis A C, Wims M, Spotts G D, Hann S R, Bradley A

Abstract excerpt

To directly assess c-myc function in cellular proliferation, differentiation, and embryogenesis, we have used homologous recombination in embryonic stem cells to generate both heterozygous and homozygous c-myc mutant ES cell lines. The mutation is a null allele at the protein level. Mouse chimera...

Topics

Alleles
Animals
Base Sequence
Blotting, Southern
Cell Differentiation
Chromosome Aberrations
Chromosome Disorders
DNA
Electrophoresis, Polyacrylamide Gel
Embryo, Mammalian
Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Fetal Death

Genes, Lethal

Genes, myc

Heterozygote

Homozygote

Infertility

Source

Open in PubMed

Identifiers

PMID: 8458579
DOI: 10.1101/gad.7.4.671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8458579-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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