Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functions of c-Jun in Liver and Heart Development

31 May 1999

Abstract excerpt

Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is known about the cell types affected as well as the cause of embryonic lethality. Here we show that a fraction of mutant E13.0 fetal livers exhibits extensive apoptosis of both hematopoietic cells and hepatoblasts, whereas the expression of 15 mRNAs, including those of albumin, keratin 18, hepatocyte nuclear factor 1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Genetics and Neurodevelopmental Disorders
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10352021
DOI: 10.1083/jcb.145.5.1049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functions of c-Jun in Liver and Heart DevelopmentPMID 10352021Read ↗

c-jun is essential for normal mouse development and hepatogenesis.Semantic proximity Read ↗

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.Semantic proximity Read ↗

The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.Semantic proximity Read ↗

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53.Semantic proximity Read ↗

Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity.Semantic proximity Read ↗

K-ras is an essential gene in the mouse with partial functional overlap with N-ras.Semantic proximity Read ↗

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene.Semantic proximity Read ↗

Jun is required in Isl1-expressing progenitor cells for cardiovascular development.Semantic proximity Read ↗

The C/EBP family of transcription factors in the liver and other organsSemantic proximity Read ↗

JunB can substitute for Jun in mouse development and cell proliferation.Semantic proximity Read ↗

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.Semantic proximity Read ↗

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.