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Article

c-jun is essential for normal mouse development and hepatogenesis.

Nature - 9 Sept 1993

Hilberg F, Aguzzi A, Howells N, Wagner E F

Abstract excerpt

The proto-oncogene c-jun is the cellular homologue of v-jun, the transforming oncogene of the avian sarcoma virus 17 (ref. 1). c-jun encodes one major component of the AP-1 transcription factor complex and is expressed in many organs during mouse development and in the adult. Because of its rapid induction in cells following growth stimulation and the presence of AP-1 binding sites in the promoter regions of many...

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Identifiers

PMID: 8371760
DOI: 10.1038/365179a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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c-jun is essential for normal mouse development and hepatogenesis.PMID 8371760Read ↗

Functions of c-Jun in Liver and Heart DevelopmentSemantic proximity Read ↗

Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity.Semantic proximity Read ↗

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.Semantic proximity Read ↗

K-ras is an essential gene in the mouse with partial functional overlap with N-ras.Semantic proximity Read ↗

Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.Semantic proximity Read ↗

Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function.Semantic proximity Read ↗

The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.Semantic proximity Read ↗

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling.Semantic proximity Read ↗

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.Semantic proximity Read ↗

JunB can substitute for Jun in mouse development and cell proliferation.Semantic proximity Read ↗

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53.Semantic proximity Read ↗

The role of c-Jun for beating cardiomycyte formation in prepared embryonic bodySemantic proximity Read ↗

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