Article
Pleiotropic effects of a null mutation in the c-fos proto-oncogene.
Cell - 13 Nov 1992
Johnson R S, Spiegelman B M, Papaioannou V
Abstract excerpt
The c-fos proto-oncogene has been implicated as a central regulatory component of the nuclear response to mitogens and other extracellular stimuli. Embryonic stem cells targeted at the c-fos locus have been used to generate chimeric mice that have transmitted the mutated allele through the germli...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Chimera
- Female
- Gametogenesis
- Genes, fos
- Hematopoiesis, Extramedullary
- Lymphopenia
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Osteopetrosis
- Polymerase Chain Reaction