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Article

The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair.

Molecular and cellular biology - 1 Jun 2004

Mahajan Muktar A, Das Sharmistha, Zhu Hong, Tomic-Canic Marjana, Samuels Herbert H

Abstract excerpt

Nuclear hormone receptor coregulator (NRC) is a 2,063-amino-acid coregulator of nuclear hormone receptors and other transcription factors (e.g., c-Fos, c-Jun, and NF-kappaB). We and others have generated C57BL/6-129S6 hybrid (C57/129) NRC(+/-) mice that appear outwardly normal and grow and reproduce. In contrast, homozygous deletion of the NRC gene is embryonic lethal. NRC(-/-) embryos are always smaller than...

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Identifiers

PMID: 15143190
DOI: 10.1128/MCB.24.11.4994-5004.2004
PMCID: PMC416394

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Source receipt: pubmed, retrieved 7 Sept 2026.

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