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Article

In vivo and in vitro studies of a copy number mutation of the RepA replication protein of plasmid pSC101.

Journal of bacteriology - 1 Jul 1993

Xia G, Manen D, Yu Y, Caro L

Abstract excerpt

The RepA replication protein of plasmid pSC101 binds as a monomer to three repeated sequences (RS1, RS2, and RS3) in the replication origin of the plasmid to initiate duplication and binds as a dimer to two inversely repeated sequences (IR1 and IR2) in its promoter region (D. Manen, L. C. Upegui-...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Binding, Competitive
DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Replication

DNA, Bacterial

DNA-Binding Proteins

Escherichia coli

Escherichia coli Proteins

Gene Expression Regulation, Bacterial

Molecular Sequence Data

Mutation

Plasmids

Promoter Regions, Genetic

Proteins

Recombinant Fusion Proteins

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 8320230
DOI: 10.1128/jb.175.13.4165-4175.1993
PMCID: PMC204846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8320230-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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In vivo and in vitro studies of a copy number mutation of the RepA replication protein of plasmid pSC101.PMID 8320230Read ↗

A copy-number mutant of plasmid pSC101.Semantic proximity Read ↗

Replication origin mutations affecting binding of pSC101 plasmid-encoded Rep initiator protein.Semantic proximity Read ↗

Analysis of a copy number mutant of plasmid pSC101: co-maintenance of wild type and mutant plasmids.Semantic proximity Read ↗

Excess intracellular concentration of the pSC101 RepA protein interferes with both plasmid DNA replication and partitioning.Semantic proximity Read ↗

Control of ColE2 DNA replication: in vitro binding of the antisense RNA to the Rep mRNA.Semantic proximity Read ↗

Regulation of replication of plasmid R1: an analysis of the intergenic region between copA and repA.Semantic proximity Read ↗

The RepA protein of plasmid pSC101 controls Escherichia coli cell division through the SOS response.Semantic proximity Read ↗

Isolation and characterization of novel mutations in the pSC101 origin that increase copy number.Semantic proximity Read ↗

Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.Semantic proximity Read ↗

Location of a P1 plasmid replication inhibitor determinant within the initiator gene.Semantic proximity Read ↗

Structural changes in RepA, a plasmid replication initiator, upon binding to origin DNA.Semantic proximity Read ↗

Control of ColE2 plasmid replication: regulation of Rep expression by a plasmid-coded antisense RNA.Semantic proximity Read ↗

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