Location of a P1 plasmid replication inhibitor determinant within the initiator gene.

doi:10.1128/jb.172.8.4441-4447.1990

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Article

Location of a P1 plasmid replication inhibitor determinant within the initiator gene.

Journal of bacteriology - 1 Aug 1990

Muraiso K, Mukhopadhyay G, Chattoraj D K

Abstract excerpt

The P1 plasmid replication initiator protein, RepA, binds to its own promoter and represses transcription efficiently. There are only about 20 RepA dimers present per repA gene. A possible reason for this highly restrained expression became evident when repA expression was increased by using foreign promoters: with fivefold overexpression, the replication rate was diminished, and with 40-fold overexpression,...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Codon
Coliphages
DNA Helicases
DNA Replication
DNA-Binding Proteins
Escherichia coli
Gene Expression Regulation, Bacterial
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Plasmids

Promoter Regions, Genetic

Proteins

Proviruses

Replicon

Source

Open in PubMed Open full text

Identifiers

PMID: 2198259
DOI: 10.1128/jb.172.8.4441-4447.1990
PMCID: PMC213273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2198259-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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