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Article

Structural changes in RepA, a plasmid replication initiator, upon binding to origin DNA.

The Journal of biological chemistry - 16 May 2003

Díaz-López Teresa, Lages-Gonzalo Marta, Serrano-López Ana, Alfonso Carlos, Rivas Germán, Díaz-Orejas Ramón, Giraldo Rafael

Abstract excerpt

RepA protein is the DNA replication initiator of the Pseudomonas plasmid pPS10. RepA dimers bind to an inversely repeated operator sequence in repA promoter, thus repressing its own synthesis, whereas monomers bind to four directly repeated sequences (iterons) to initiate DNA replication. We had proposed previously that RepA is composed of two winged-helix (WH) domains, a structural unit also present in...

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PMID: 12637554
DOI: 10.1074/jbc.M212024200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural changes in RepA, a plasmid replication initiator, upon binding to origin DNA.PMID 12637554Read ↗

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