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Article

Regulation of replication of plasmid R1: an analysis of the intergenic region between copA and repA.

Molecular & general genetics : MGG - 1 Nov 1991

Ohman M, Wagner E G

Abstract excerpt

The synthesis of the rate-limiting RepA replication initiator protein of plasmid R1 is negatively controlled by an antisense RNA, CopA. The regulation is posttranscriptional and involves an inhibitory effect on RepA translation mediated by the binding of CopA to its target (CopT) in the leader region of the RepA mRNA. The evolutionary conservation of the intergenic region between the copA gene and the repA...

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Identifiers

PMID: 1720863
DOI: 10.1007/BF00290683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of replication of plasmid R1: an analysis of the intergenic region between copA and repA.PMID 1720863Read ↗

Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.Semantic proximity Read ↗

Control of replication of plasmid R1: the duplex between the antisense RNA, CopA, and its target, CopT, is processed specifically in vivo and in vitro by RNase III.Semantic proximity Read ↗

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Control of ColE2 DNA replication: in vitro binding of the antisense RNA to the Rep mRNA.Semantic proximity Read ↗

Regulation of plasmid R1 replication: PcnB and RNase E expedite the decay of the antisense RNA, CopA.Semantic proximity Read ↗

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Bulged residues promote the progression of a loop-loop interaction to a stable and inhibitory antisense-target RNA complex.Semantic proximity Read ↗

The plasmid ColIb-P9 antisense Inc RNA controls expression of the RepZ replication protein and its positive regulator repY with different mechanisms.Semantic proximity Read ↗

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