Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.

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Article

Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.

Molecular microbiology - 1 Jan 1991

Berzal-Herranz A, Wagner E G, Díaz-Orejas R

Abstract excerpt

The RepA protein of plasmid R1 is rate-limiting for initiation of R1 replication. Its synthesis is mainly regulated by interactions of the antisense RNA, CopA, with the leader region of the RepA mRNA, CopT. This work describes the characterization of several mutants with sequence alterations in the intergenic region between the copA gene and the repA reading frame. The analysis showed that most of the mutations...

Topics

Bacterial Proteins
Base Sequence
Blotting, Northern
DNA Helicases
DNA Replication
DNA, Bacterial
DNA-Binding Proteins
Gene Expression Regulation, Bacterial
Introns
Kinetics
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Conformation

Open Reading Frames

Proteins

R Factors

RNA, Antisense

RNA, Bacterial

Source

Open in PubMed

Identifiers

PMID: 1707477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1707477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.PMID 1707477Read ↗

Regulation of replication of plasmid R1: an analysis of the intergenic region between copA and repA.Semantic proximity Read ↗

Control of replication of plasmid R1: the duplex between the antisense RNA, CopA, and its target, CopT, is processed specifically in vivo and in vitro by RNase III.Semantic proximity Read ↗

Control of ColE2 plasmid replication: regulation of Rep expression by a plasmid-coded antisense RNA.Semantic proximity Read ↗

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Control of ColE2 DNA replication: in vitro binding of the antisense RNA to the Rep mRNA.Semantic proximity Read ↗

Location of a P1 plasmid replication inhibitor determinant within the initiator gene.Semantic proximity Read ↗

Regulation of plasmid R1 replication: PcnB and RNase E expedite the decay of the antisense RNA, CopA.Semantic proximity Read ↗

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Bulged residues promote the progression of a loop-loop interaction to a stable and inhibitory antisense-target RNA complex.Semantic proximity Read ↗

In vivo and in vitro studies of a copy number mutation of the RepA replication protein of plasmid pSC101.Semantic proximity Read ↗

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