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Article

Sites and types of p53 mutations in an unselected series of colorectal cancers in The Netherlands.

Anticancer research - 1 Jan 2000

Van Den Broek M H, Renault B, Fodde R, Verspaget H, Griffioen G, Khan P M

Abstract excerpt

An unselected series of colorectal adenocarcinomas together with their corresponding normal mucosa, derived from 24 Dutch patients, was investigated for the loss of a marker mapping close to the region of p53 on chromosome 17p and for mutations in exons 5, 6, 7 and 8 of the p53 gene. The observed loss of heterozygosity of the marker on chromosome 17p was 36% of the informative cases, while 58% of the tumors...

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PMID: 8317886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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