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Article

Base transitions are the most frequent genetic changes at P53 in gastric cancer.

Cancer research - 1 Jun 1993

Renault B, van den Broek M, Fodde R, Wijnen J, Pellegata N S, Amadori D, Khan P M, Ranzani G N

Abstract excerpt

We searched for P53 mutations in gastric carcinoma by analyzing tumor DNAs from 29 patients. We detected 13 different somatic mutations in 15 patients (52%) and a biallelic polymorphism in exon 6 (5 heterozygous subjects). The somatic mutations were mainly localized in the sequences corresponding to the highly conserved domains of the protein. Twelve samples showed a single base change: 11 missense and 1 nonsense...

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PMID: 8495424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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