Prognostic significance of the loss of heterozygosity of Nm23-H1 and p53 genes in human colorectal carcinomas.

doi:10.1002/1097-0142(19940615)73:12<2913::aid-cncr2820731207>3.0.co;2-l

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Article

Prognostic significance of the loss of heterozygosity of Nm23-H1 and p53 genes in human colorectal carcinomas.

Cancer - 15 Jun 1994

Campo E, Miquel R, Jares P, Bosch F, Juan M, Leone A, Vives J, Cardesa A, Yague J

Abstract excerpt

BACKGROUND: Nm23 is a gene associated with low tumor metastatic potential and has been proposed to be a metastasis suppressor gene. Nm23 is localized on chromosome 17q21.3-22, whereas the p53 suppressor gene is on 17p13. Allelic deletions of chromosome 17 have been related to the progression of colorectal carcinomas. The purpose of this study was to analyze the allelic deletions of Nm23 and p53 in colorectal...

Topics

Adenocarcinoma
Aged
Alleles
Aneuploidy
Base Sequence
Blotting, Southern
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
Colorectal Neoplasms
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Deletion

Genes, p53

Heterozygote

Humans

Male

Molecular Sequence Data

Monomeric GTP-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 8199988
DOI: 10.1002/1097-0142(19940615)73:12<2913::aid-cncr2820731207>3.0.co;2-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8199988-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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