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Article

Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease.

Neurology - 1 Feb 1994

Brousseau T, Legrain S, Berr C, Gourlet V, Vidal O, Amouyel P

Abstract excerpt

Family studies indicate a possible linkage between the q13.2 region of chromosome 19 and Alzheimer's disease (AD). An isoform of apolipoprotein E, whose gene maps in this region, is more frequent in AD. In this study, we investigated the possible association of a genetic polymorphism of the apolipoprotein E gene with late-onset AD. We compared apolipoprotein E polymorphism distribution between patients with...

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PMID: 8309588
DOI: 10.1212/wnl.44.2.342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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