Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease.

doi:10.1212/wnl.44.2.342

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Article

Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease.

Neurology - 1 Feb 1994

Brousseau T, Legrain S, Berr C, Gourlet V, Vidal O, Amouyel P

Abstract excerpt

Family studies indicate a possible linkage between the q13.2 region of chromosome 19 and Alzheimer's disease (AD). An isoform of apolipoprotein E, whose gene maps in this region, is more frequent in AD. In this study, we investigated the possible association of a genetic polymorphism of the apoli...

Topics

Age Factors
Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Female
Genotype
Humans
Male
Reference Values
Risk Factors

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