Article
Apolipoprotein E polymorphism and Alzheimer's disease.
Lancet (London, England) - 18 Sept 1993
Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S
Abstract excerpt
Apolipoprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. It also appears to play an important part in the redistribution of lipids that follows deafferentation and neurodegeneration in the brain. The gene for apoE is on chromosome...
Topics
- Age Factors
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Chromosomes, Human, Pair 19
- Female
- Gene Frequency
- Humans
- Male
- Neurofibrillary Tangles
- Phenotype
- Polymorphism, Genetic