Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1993

Strittmatter W J, Saunders A M, Schmechel D, Pericak-Vance M, Enghild J, Salvesen G S, Roses A D

Abstract excerpt

Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque) with high avidity. Amino acids 12-28 of the beta A4 peptide are required. The gene for apolipoprotein E is located on chromosome 19q13.2, within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amino Acid Sequence

Share to Apolipoproteins E

Share to Gene Frequency

Share to Molecular Sequence Data

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 8446617
DOI: 10.1073/pnas.90.5.1977
PMCID: PMC46003

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.PMID 8446617Read ↗

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.Semantic proximity Read ↗

Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease.Semantic proximity Read ↗

[Apolipoprotein E4 and late-onset Alzheimer's disease].Semantic proximity Read ↗

Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.Semantic proximity Read ↗

Apolipoprotein E: risk factor for Alzheimer disease.Semantic proximity Read ↗

[The apolipoprotein E-epsilon 4 allele is a risk factor for Alzheimer disease with early and late onset].Semantic proximity Read ↗

Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E polymorphism and Alzheimer's disease.Semantic proximity Read ↗

Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study.Semantic proximity Read ↗

Apolipoprotein E and Alzheimer's disease.Semantic proximity Read ↗

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.Semantic proximity Read ↗

The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.