A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.

doi:10.4088/jcp.v68n0419

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Article

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.

The Journal of clinical psychiatry - 1 Apr 2007

Coon Keith D, Myers Amanda J, Craig David W, Webster Jennifer A, Pearson John V, Lince Diane Hu, Zismann Victoria L, Beach Thomas G, Leung Doris, Bryden Leslie, Halperin Rebecca F, Marlowe Lauren, Kaleem Mona, Walker Douglas G, Ravid Rivka, Heward Christopher B, Rogers Joseph, Papassotiropoulos Andreas, Reiman Eric M, Hardy John, Stephan Dietrich A

Abstract excerpt

OBJECTIVE: While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19. Recently developed methods for the simultaneous assessment of hundreds of thousands of single nucleotide polymorphisms (SNPs) promise to help more precisely identify...

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PMID: 17474819
DOI: 10.4088/jcp.v68n0419

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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