Article
Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.
Human molecular genetics - 1 Apr 1994
Chartier-Harlin M C, Parfitt M, Legrain S, Pérez-Tur J, Brousseau T, Evans A, Berr C, Vidal O, Roques P, Gourlet V
Abstract excerpt
An association between the 19q13.2 chromosomal region and Alzheimer's disease (AD) has been reported in AD families and for sporadic AD. Recent observations provide evidence that the epsilon 4 allele of the apolipoprotein E gene (APOE), located in this region, is a risk factor for late-onset AD. Within this region, other genes possibly involved in the pathophysiology of AD and in strong linkage disequilibrium...
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