The p53 tumor suppressor gene frequently is altered in gynecologic cancers.

doi:10.1016/s0002-9378(94)70414-7

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Article

The p53 tumor suppressor gene frequently is altered in gynecologic cancers.

American journal of obstetrics and gynecology - 1 Jan 1994

Berchuck A, Kohler M F, Marks J R, Wiseman R, Boyd J, Bast R C

Abstract excerpt

Mutation of the p53 tumor suppressor gene, often accompanied by overexpression of mutant p53 protein, is the most frequent molecular genetic event described thus far in human cancers. In adenocarcinomas of the ovary and endometrium, p53 overexpression is seen in approximately 10% to 15% of early...

Topics

Adenocarcinoma
Carcinoma, Squamous Cell
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Genital Neoplasms, Female
Humans
Mutation
Neoplasms, Germ Cell and Embryonal
Sarcoma
Tumor Suppressor Protein p53

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