The p53 tumor suppressor gene as a common cellular target in human carcinogenesis.

Article

The p53 tumor suppressor gene as a common cellular target in human carcinogenesis.

The American journal of gastroenterology - 1 Feb 1993

Chang F, Syrjänen S, Kurvinen K, Syrjänen K

Abstract excerpt

The p53 gene is a 16-20 kb of cellular DNA located on the short arm of human chromosome 17 at position 17p13.1. This gene encodes a 375-amino acid nuclear phosphoprotein which involves in the regulation of cell proliferation. The p53 gene was originally regarded as a dominant oncogene because its...

Topics

Amino Acid Sequence
Animals
Cell Transformation, Neoplastic
Gastrointestinal Neoplasms
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasms
Tumor Suppressor Protein p53

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