Article
The p53 tumor suppressor gene as a common cellular target in human carcinogenesis.
The American journal of gastroenterology - 1 Feb 1993
Chang F, Syrjänen S, Kurvinen K, Syrjänen K
Abstract excerpt
The p53 gene is a 16-20 kb of cellular DNA located on the short arm of human chromosome 17 at position 17p13.1. This gene encodes a 375-amino acid nuclear phosphoprotein which involves in the regulation of cell proliferation. The p53 gene was originally regarded as a dominant oncogene because its overexpression resulted in the immortalization of rodent cells, and the p53 gene could transform rat embryonic...
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