Article
p53 alteration independently predicts poor outcomes in patients with endometrial cancer: a clinicopathologic study of 131 cases and literature review.
Gynecologic oncology - 1 Mar 2010
Lee Eun-Ju, Kim Tae-Joong, Kim Dae Shick, Choi Chel Hun, Lee Jeong-Won, Lee Je-Ho, Bae Duk-Soo, Kim Byoung-Gie
Abstract excerpt
OBJECTIVE: The aim of this study was to evaluate the prognostic impact of p53 alteration in human uterine endometrial adenocarcinoma. METHODS: One hundred and thirty-one patients with primary endometrial adenocarcinoma were included in the study. The p53 mutation and/or protein expression were evaluated by polymerase chain reaction-single-strand conformational polymorphism and by immunohistochemical analysis,...
Topics
- Adenocarcinoma
- Adult
- Aged
- Endometrial Neoplasms
- Exons
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Prognosis