Article
Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes.
Japanese journal of cancer research : Gann - 1 Nov 1992
Tsuda H, Hirohashi S
Abstract excerpt
The clinical and pathological significance of mutation of the p53 tumor-suppressor gene was examined in 108 cases of primary uterine cancers using single-strand conformation polymorphism and direct DNA sequencing analyses. Mutation of the p53 gene was detected in 19 (31%) of 62 cases of cancer of...
Topics
- Adenocarcinoma
- Base Sequence
- Codon
- DNA, Neoplasm
- DNA, Single-Stranded
- DNA, Viral
- Exons
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Neoplasm Staging
- Papillomaviridae
- Phenotype
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic