Li-Fraumeni syndrome and the role of the p53 tumor suppressor gene in cancer susceptibility.

Abstract excerpt

Mutation of the tumor suppressor gene p53 is a molecular genetic event frequently observed in human cancer, and inactivating missense mutations usually are accompanied by the resultant overexpression of mutant p53 protein. In gynecologic cancers, p53 is also often altered; the frequency varies depending on types of cancers and where they develop. Further, human papillomavirus oncoproteins that inactivate p53 and...

Topics

• Female
• Gene Expression Regulation
• Genes, p53
• Genetic Predisposition to Disease
• Genetic Therapy
• Genital Neoplasms, Female
• Germ-Line Mutation
• Humans
• Li-Fraumeni Syndrome
• Neoplastic Syndromes, Hereditary
• Transcription, Genetic