Article
[Analysis of p53 gene in gynecologic tumors].
Rinsho byori. The Japanese journal of clinical pathology - 1 Mar 1994
Yaginuma Y, Yamashita T, Duenas J C, Katayama H, Ishikawa M
Abstract excerpt
The inactivation of the tumor suppressor gene p53 has been demonstrated in a variety of human tumors. Herein, we performed a p53 gene analysis of human gynecologic tumor cell lines and tumor tissues. In the SK-OV-3 cell line, Southern analysis suggested the presence of sequence deletions/rearrangements in at least one allele of p53 gene. Transcripts were not detectable by either Northern or PCR analysis....
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