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Article

The role of TP53 in Cervical carcinogenesis.

Human mutation - 1 Mar 2003

Tommasino Massimo, Accardi Rosita, Caldeira Sandra, Dong Wen, Malanchi Ilaria, Smet Anouk, Zehbe Ingeborg

Abstract excerpt

Functional loss of the tumor suppressor p53 by alterations in its TP53 gene is a frequent event in cancers of different anatomical regions. Cervical cancer is strongly linked to infection by high-risk human papillomavirus (HPV) types. The viral oncoprotein E6 has the ability to associate with and neutralize the function of p53. E6 interacts with a 100-kDa cellular protein, termed E6 associated protein (E6AP; also...

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Source

Identifiers

PMID: 12619117
DOI: 10.1002/humu.10178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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