p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis.

Article

p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis.

The American journal of pathology - 1 Jan 1997

Tashiro H, Isacson C, Levine R, Kurman R J, Cho K R, Hedrick L

Abstract excerpt

Uterine serous carcinoma (USC) is an uncommon but aggressive type of endometrial cancer associated with rapid progression of disease and a poor prognosis. Both USC and its recently described putative precursor, endometrial intraepithelial carcinoma (EIC), demonstrate strong p53 overexpression by...

Topics

Aged
Aged, 80 and over
Chromosomes, Human, Pair 17
Cystadenocarcinoma
Endometrial Neoplasms
Female
Genes, p53
Heterozygote
Humans
Immunohistochemistry
Middle Aged
Mutation

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