Mutation and overexpression of the p53 tumor suppressor gene frequently occurs in uterine and ovarian sarcomas.

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Article

Mutation and overexpression of the p53 tumor suppressor gene frequently occurs in uterine and ovarian sarcomas.

Obstetrics and gynecology - 1 Jan 1994

Liu F S, Kohler M F, Marks J R, Bast R C, Boyd J, Berchuck A

Abstract excerpt

OBJECTIVE: To determine the frequency of mutation and overexpression of the p53 tumor suppressor gene in female genital tract sarcomas. METHODS: Immunostaining for p53 was performed in frozen sections of 46 ovarian and uterine sarcomas. Single-stranded conformation polymorphism analysis of exons...

Topics

Adult
Aged
Aged, 80 and over
DNA, Neoplasm
Exons
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Middle Aged
Mutation
Ovarian Neoplasms
Polymorphism, Genetic
Sarcoma
Uterine Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8272291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8272291-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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