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Article

N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.

The Biochemical journal - 15 Dec 1993

Velan B, Kronman C, Ordentlich A, Flashner Y, Leitner M, Cohen S, Shafferman A

Abstract excerpt

The role of N-glycosylation in the function of human acetylcholinesterase (HuAChE) was examined by site-directed mutagenesis (Asn to Gln substitution) of the three potential N-glycosylation sites Asn-265, Asn-350 and Asn-464. Analysis of HuAChE mutants, defective in a single or multiple N-glycosylation sites, by expression in transiently or stably transfected human embryonal 293 kidney cells suggests the...

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Identifiers

PMID: 8280063
DOI: 10.1042/bj2960649
PMCID: PMC1137746

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