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Article

Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor.

The FEBS journal - 1 Jun 2012

Gellynck Evelien, Andressen Kjetil W, Lintermans Béatrice, Haegeman Guy, Levy Finn O, Vanhoenacker Peter, Van Craenenbroeck Kathleen

Abstract excerpt

The 5-hydroxytryptamine (5-HT)(7(a)) receptor is a G-protein-coupled receptor critically involved in human psychiatric and neurological disorders. In the present study, we evaluate the presence and the functional role of N-glycosylation of the human 5-HT(7) receptor. Western blot analysis of HEK293T cells transiently expressing the 5-HT(7(a)) receptor in the presence of tunicamycin gave rise to a band shift,...

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Identifiers

PMID: 22448645
DOI: 10.1111/j.1742-4658.2012.08581.x

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