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Article

Functional requirements for the optimal catalytic configuration of the AChE active center.

Chemico-biological interactions - 15 Dec 2005

Shafferman Avigdor, Barak Dov, Kaplan Dana, Ordentlich Arie, Kronman Chanoch, Velan Baruch

Abstract excerpt

Functional analysis of the HuAChE active center architecture revealed that accommodation of structurally diverse substrates and other ligands is achieved through interactions with specific subsites such as the acyl pocket, cation binding site, hydrophobic site or the oxyanion hole. Recent studies have begun to unravel the role of this active center architecture in maintaining the optimal catalytic facility of the...

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PMID: 16256968
DOI: 10.1016/j.cbi.2005.10.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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