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Article

Expression of human AChR extracellular domain mutants with improved characteristics.

International journal of biological macromolecules - 1 Feb 2014

Lazaridis Konstantinos, Zisimopoulou Paraskevi, Giastas Petros, Bitzopoulou Kalliopi, Evangelakou Panagiota, Sideri Anastasia, Tzartos Socrates J

Abstract excerpt

The muscle nicotinic acetylcholine receptor (AChR) has a central role in neuromuscular transmission, and is the major target in the autoimmune disease myasthenia gravis (MG). We created mutants of the extracellular domains (ECDs) of the human α1, β1, δ and ε AChR subunits, whereby their Cys-loop was exchanged for that of the acetylcholine binding protein. The mutants were expressed in Pichia pastoris and had...

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Identifiers

PMID: 24246999
DOI: 10.1016/j.ijbiomac.2013.11.003

Genes

ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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