Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

N-glycosylation sites on the nicotinic ACh receptor subunits regulate receptor channel desensitization and conductance.

Brain research. Molecular brain research - 10 Jun 2003

Nishizaki Tomoyuki

Abstract excerpt

The present study investigated the effects of N-glycosylation sites on Torpedo acetylcholine (ACh) receptors expressed in Xenopus oocytes by monitoring whole-cell membrane currents and single-channel currents from excised patches. Receptors with the mutant subunit at the asparagine residue on the conserved N-glycosylation site (mbetaN141D, mgammaN141D, or mdeltaN143D) or the serine/threonine residue (mbetaT143A,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation
Share to Ion Channels
Share to Membrane Potentials

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oocytes

Share to Receptors, Nicotinic

Share to Synaptic Transmission

Share to Torpedo

Share to Xenopus

Source

Identifiers

PMID: 12829329
DOI: 10.1016/s0169-328x(03)00171-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-glycosylation sites on the nicotinic ACh receptor subunits regulate receptor channel desensitization and conductance.PMID 12829329Read ↗

Contributions of N-linked glycosylation to the expression of a functional alpha7-nicotinic receptor in Xenopus oocytes.Semantic proximity Read ↗

Lectin-induced inhibition of desensitization of the kainate receptor GluR6 depends on the activation state and can be mediated by a single native or ectopic N-linked carbohydrate side chain.Semantic proximity Read ↗

Structure, diversity, and ionic permeability of neuronal and muscle acetylcholine receptors.Semantic proximity Read ↗

The coupling interface and pore domain codetermine the single-channel activity of the α7 nicotinic receptor.Semantic proximity Read ↗

Mutations in the M4 domain of the Torpedo californica nicotinic acetylcholine receptor alter channel opening and closing.Semantic proximity Read ↗

Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.Semantic proximity Read ↗

Novel G423S mutation of human alpha7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanism.Semantic proximity Read ↗

Mutants of β-strand β3 and the loop B in the interface between α7 subunits of a homomeric acetylcholine receptor show functional and pharmacological alterations.Semantic proximity Read ↗

Effects of Kv1.1 channel glycosylation on C-type inactivation and simulated action potentials.Semantic proximity Read ↗

Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channelsSemantic proximity Read ↗

Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors.Semantic proximity Read ↗

Role of phosphorylation in desensitization of acetylcholine receptors expressed in Xenopus oocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.