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Article

Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.

1 Mar 1994

Abstract excerpt

Several of the residues constituting the peripheral anionic site (PAS) in human acetylcholinesterase (HuAChE) were identified by a combination of kinetic studies with 19 single and multiple HuAChE mutants, fluorescence binding studies with the Trp-286 mutant, and by molecular modeling. Mutants were analyzed with three structurally distinct positively charged PAS ligands, propidium, decamethonium, and...

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PMID: 8119978
DOI: 10.1016/s0021-9258(17)37371-4

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