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Hierarchy of Post-translational Modifications Involved in the Circulatory Longevity of Glycoproteins

1 Sept 2000

Abstract excerpt

The tetrameric form of native serum-derived bovine acetylcholinesterase is retained in the circulation for much longer periods (mean residence time, MRT = 1390 min) than recombinant bovine acetylcholinesterase (rBoAChE) produced in the HEK-293 cell system (MRT = 57 min). Extensive matrix-assisted laser desorption ionization-time of flight analyses established that the basic structures of the N-glycans associated...

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PMID: 10867010
DOI: 10.1074/jbc.m004298200

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