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Article

Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.

Molecular pharmacology - 1 Mar 1994

Ashani Y, Grunwald J, Kronman C, Velan B, Shafferman A

Abstract excerpt

Huperzine A (HUP), a natural, potent, 'slow,' reversible inhibitor of antiacetylcholinesterase (AChE), has been suggested to be superior to antiacetylcholinesterase drugs now being used for management of Alzheimer's disease. To delineate the binding site of human AChE (HuAChE) for HUP, the biochemical constants kon, koff, and Ki were determined for complexes formed between HUP and single-site (Y337F, Y337A,...

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PMID: 8145739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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