Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.

Article

Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.

Molecular pharmacology - 1 Mar 1994

Ashani Y, Grunwald J, Kronman C, Velan B, Shafferman A

Abstract excerpt

Huperzine A (HUP), a natural, potent, 'slow,' reversible inhibitor of antiacetylcholinesterase (AChE), has been suggested to be superior to antiacetylcholinesterase drugs now being used for management of Alzheimer's disease. To delineate the binding site of human AChE (HuAChE) for HUP, the bioche...

Topics

Acetylcholinesterase
Alkaloids
Binding Sites
Cell Line
Cholinesterase Inhibitors
Humans
Hydrogen-Ion Concentration
Mutation
Sesquiterpenes
Tyrosine

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