Article
Successive organophosphate inhibition and oxime reactivation reveals distinct responses of recombinant human cholinesterase variants.
Brain research. Molecular brain research - 1 Jul 1995
Schwarz M, Loewenstein-Lichtenstein Y, Glick D, Liao J, Norgaard-Pedersen B, Soreq H
Abstract excerpt
To explore the molecular basis of the biochemical differences among acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and their alternative splicing and allelic variants, we investigated the acylation phase of cholinesterase catalysis, using phosphorylation as an analogous reaction. Rate constants for organophosphate (DFP) inactivation, as well as for oxime (PAM)-promoted reactivation, were calculated...
Topics
- Acetylcholinesterase
- Alleles
- Alternative Splicing
- Animals
- Butyrylcholinesterase
- Catalysis
- Cholinesterase Inhibitors
- Cholinesterase Reactivators
- Genetic Variation
- Humans