Article
Antigenic heterogeneity of Qa-2 antigens in C57BL/6.
Microbiology and immunology - 1 Jan 1993
Park E, Shinohara N, Arn J S, Sharrow S O, Waneck G L, Sacks D H
Abstract excerpt
The Qa-2 antigens are class I-like molecules encoded by genes mapped telomeric to the H-2D region on chromosome 17 in the mouse. A panel of 8 new monoclonal anti-Qa-2 antibodies derived from a C3H.KBR anti-C3H. SW immunization was studied. Immunoprecipitation of 125I-labeled C57BL/6 splenocyte antigens showed that all of these antibodies precipitated 40 kDa molecules which could be completely precleared by the...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Cross Reactions
- Genes, MHC Class I
- Genetic Variation
- H-2 Antigens
- Histocompatibility Antigens Class I
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Precipitin Tests
- Spleen
- Transfection