Article
Alloreactive monoclonal antibodies select Kd molecules with different peptide profiles.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1996
Noun G, Reboul M, Abastado J P, Jaulin C, Kourilsky P, Pla M
Abstract excerpt
As a part of our continuing effort to study the antigenic structure of class I molecules, we have undertaken two types of studies. First, we have studied the capacity of five different Kd-reactive mAbs to recognize a panel of 25 site-directed mutants of the H-2Kd molecule. Both the gain and the decrease in Ab binding resulted from a single amino acid substitution at different positions. All mutations that...
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